Authors : P. P. Chahande
Page Nos : 440-445
Description :
Co-crystal are being studied largely in the modern day because they have the ability to modify the physical properties of solid state materials particularly pharmaceuticals. cocrystals has in necessitated additional research on methods to make co-crystals that can offer environmentally attractive and effective options. Co-crystallization alters the molecular interaction. They also alter the composition of pharmaceuticals materials. Co-crystals consist of API and stoichiometric amount of acceptable co-crystal forms, Pharmaceutical co-crystals is an approach to find out solubility and dissolution of drugs. Paracetamol is non-steroidal anti-inflammatory drug. The present study aim to increase the solubility of drug and dissolution. Co-crystals can be constructed through several types of interaction, including hydrogen bonding, pi-stacking and wander walls forces.
